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Assume 2 is rational The quantity 21/2 can be represented as a ratio of two integers, p and q, in lowest terms 21/2 = p /q (21/2)2 = (p /q)2 2 = p2/q2 2q2 = p2 q2 = p2/2 We know q is an integer, so q2 is an integer We know p is an integer, so p2 is an integer p2/2 is an integer p2 is an even integer p is an even integer p /2 is an integer Call p /2 = t p = 2t 2q2 = (2t)2 2q2 = 4t2 q2/2 = t2 We know t is an integer, so t2 is an integer q2/2 is an integer q2 is an even integer q is an even integer q /2 is an integer The quotient p /q is a ratio of integers in lowest terms p /2 is an integer, and q /2 is an integer (p /2)/(q /2) is a ratio of integers The ratio p /q is not given in lowest terms We have produced a logical absurdity 21/2 is not rational Q.E.D.

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Symptomatic palatal tremor, in contrast to the essential type and all other tremors, persists during sleep and is sometimes associated with oscillopsia and unilateral or bilateral cerebellar signs In some cases of the symptomatic type, the pharynx as well as the facial and extraocular muscles (pendular or convergence nystagmus), diaphragm, vocal cords, and even the muscles of the neck and shoulders partake of the persistent rhythmic movements A similar phenomenon, in which contraction of the masseters occurs concurrently with pendular ocular convergence, has been observed in Whipple disease (oculomasticatory myorhythmia) Magnetic resonance imaging reveals no lesions to account for essential palatal tremor; in the symptomatic form, however, one can see the tegmental brainstem lesions and conspicuous enlargement of the inferior olivary nucleus unilaterally or bilaterally With unilateral palatal tremor, it is the contralateral olive that becomes enlarged.

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It has been proposed that the lesions in the symptomatic form interrupt the circuit (dentate nucleus brachium conjunctivum central tegmental tract olivary nucleus dentate nucleus) that Lapresle and Ben Hamida have called the triangle of Guillain and Mollaret, (Mollaret triangle, as discussed in Chap 5) after the persons who rst carefully studied the condition (pages 72 73) Our own pathologic material con rms the central tegmental-olivary lesions but contains no examples of the production of palatal myclonus by lesions of the cerebellum or of the dentate and red nuclei The lesions have been vascular, neoplastic, demyelinating (multiple sclerosis), or traumatic and have been found in the midbrain or pontine tegmentum There are no reports on the pathologic anatomy of essential palatal tremor The physiologic basis of palatal tremor remains conjectural.

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Matsuo and Ajax postulated a denervation hypersensitivity of the inferior olivary nucleus and its dentate connections, but Kane and Thach have adduced that the critical event is denervation not of the olive but of the nucleus ambiguus and the dorsolateral reticular formation adjacent to it Dubinsky and colleagues have suggested that palatal tremor may be based on the same mechanism as postural tremor ie, presumably a disinhibition of the olive and a rhythmic coupling of neurons in the olive induced by a lesion of the dentato-olivary pathway We are uncertain whether to designate these rhythmic disorders as uniphasic myoclonus or as tremors The use of drugs in treating this movement disorder has met with variable success Clonazepam (025 to 05 mg/day, increasing gradually to 30 to 6.

0 mg/day), sodium valproate (250 mg/day, increasing to 1000 mg/day), and gabapentin have suppressed the movement in some cases, particularly the last of these drugs, which reportedly has had a dramatic effect in some patients Also, tetrabenazine and haloperidol have been helpful on occasion Selective injection of the palatal muscles with botulinum toxin affords modest relief; it is particularly helpful in eliminating the annoying ear clicking..

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