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using monotherapy, because of the inherent increased risk of nicotine overdose (Fiore et al, 2000) Use of bupropion SR in combination with the nicotine patch has been shown to increase cessation rates 52 percentage points over bupropion SR alone, from 303% to 355%, although this increase was not statistically signi cant (Jorenby et al, 1999) Thus, despite the small number of trials that have examined combination therapy versus monotherapy, the results appear promising and may be particularly applicable to refractory patients who have been unable to quit using single agents Additional research is needed to delineate more clearly the value-added effects of combination therapy, to compare the relative effects of the different constellations of agents, and to examine the comparative side effect pro les and toxicities associated with combination therapy.

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Despite the fact that several different classes of drugs have been examined in recent years for their effectiveness in promoting smoking cessation, quit rates remain low, with fewer than one third of patients being abstinent at ve or more months posttreatment Furthermore, because few studies extend beyond one year, it is not known whether cessation is maintained long term Although the nicotine transdermal patch and nicotine gum now are available without a prescription, it is not clear whether this increased access compromises ef cacy because patients can now self-prescribe and self-treat their tobacco dependence without the proven positive effects of intervention from a health professional Nonpharmaceutical Methods for Cessation Of smokers attempting to quit, many give up smoking on their own, without assistance of any kind.

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A variety of self-help materials are available; in general, these materials are just marginally more effective than no intervention, although tailored materials tend to have a greater impact than do nontailored materials (Lancaster & Stead, 2000) Social support, other than that provided by cessation counselors, has been shown to increase the likelihood of quitting by approximately 50% (Fiore et al, 2000) When feasible, smoking cessation treatment should involve some form of tobacco dependence counseling In a meta-analysis of trials assessing the effects of cessation advice from medical practitioners (Silagy & Stead, 2001), it was determined that brief advice is associated with an increased likelihood of quitting versus no advice (odds ratio, 17); in addition, more intensive advice leads to a higher likelihood of quitting when compared to more minimal advice (odds ratio, 14).

Although tobacco is the leading cause of morbidity and premature mortality in the United States, allied health professionals generally do not receive adequate tobacco cessation training The vast majority of medical.

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can be characterized as a ubiquitous, shared information space coupled to a hypermedia processing model. The Web is ubiquitous the primary Web protocols are simple and deployed in all major user-oriented computing platforms, even handheld telephony devices. The Web is a shared information space accessible data are structured content representing any data that any service provider sees t to publish. Hypermedia de ne the ability to address remote content that is organized in some known structure. The hypermedia-processing model de nes data retrieval and presentation behavior, de nes how to perform simple queries on content servers and how to push new or modi ed content back to a content server. The de nitive source for a de nition of the Web comes from the W3C TAG (Technical Architectural Group). It categorizes the Web architecture into three primary areas: . Identi cation Web processes identify resources using uniform identity identi ers (URIs) . Representation Web processes represent the state of an identi able resource . Transfer representational state transfer (REST) The Web is currently a human-initiated client server system based on browsers, document access, simple manual purchases, and le downloads. The Web owes

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If there is no resistance to molecules reaching equilibrium at the droplet surface, c (R) = c e (R, T ) and J D gives the total net mass current to the droplet. However, we do not have to make this assumption and can easily combine the diffusive and kinetic resistances to mass transfer to a droplet.

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